Detail
| LncRNA Name | SH3PXD2A-AS1 |
| Synonyms | NR_038940.1 |
| Region | GRCh38_10:103745966-103755423 Sequence |
| Ensembl | ENSG00000280693 |
| RefSeq | NR_038940 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq, Microarray, qPCR, Western blot etc. |
| Sample | colorectal cancer tissues, cell lines (SW480, DLD-1, HT-29, HCoEpiC and LOVO) |
| Expression Pattern | up-regulated |
| Function Description | We firstly found that SH3PXD2A-AS1 was significantly upregulated in CRC tissues and cell lines, and overexpression of SH3PXD2A-AS1 was correlated with tumor size, TNM stage, and lymph node metastasis in patients with CRC. Furthermore, SH3PXD2A-AS1 knockdown inhibited CRC cells proliferation, migration and invasion in vitro, and suppressed tumorigenesis in vivo. Mechanistic studies indicated that SH3PXD2A-AS1 could epiqenetically repress P57 and KLF2 expression through interaction with EZH2. Rescue experiments suggested that SH3PXD2A-ASl-mediated oncogenesis was impaired by overexpression of P57 or KLF2. Interestingly, the expression of SH3PXD2A-AS1 was inversely correlated with the expression of P57 and KLF2 in CRC tissue samples. |
| Pubmed ID | 29734178 |
| Year | 2018 |
| Title | Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer. |
| External Links |
| Links for SH3PXD2A-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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