Detail
| LncRNA Name | SIRT1-AS |
| Synonyms | SIRT1-AS |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, Northern blot etc. |
| Sample | cell line (HCC-9903) |
| Expression Pattern | up-regulated |
| Function Description | SIRT1-AS overexpression promoted the proliferation of the human HCC cell lines by upregulating the SIRT1 protein level. The mechanism was that SIRT1-AS bound to SIRT1 mRNA at 3'UTR, masked the miR-29c binding site and stabilized SIRT1 mRNA. |
| Pubmed ID | 26324025 |
| Year | 2015 |
| Title | A novel mutation in SIRT1-AS leading to a decreased risk of HCC |
| External Links |
| Links for SIRT1-AS | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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