Detail
| LncRNA Name | Skp2 |
| Synonyms | SKP2, FBL1, FBXL1, p45 |
| Region | GRCh38_5:36151989-36184319 Sequence |
| Ensembl | ENSG00000145604 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot etc. |
| Sample | NSCLC tissues, NSCLC cell lines (ATCC, Rockville, MD, USA) |
| Expression Pattern | differential expression |
| Function Description | These data suggest that the Skp2 may be regulated by Meg3 at post-transcriptional level. Bioinformatics analyses showed that miR-3163 bound to 3'-UTR of Skp2 mRNA in NSCLC cells to inhibit its translation, which was supported by luciferase reporter assay. Meg3 augmented the effects of miR-3163 on Skp2 mRNA, possibly through binding-induced function enhancement, which was supported by the double fluorescent in situ hybridization showing co-localized intracellular Meg3 and miR-3163 signals in NSCLC cells. The miR-3163 levels in NSCLC were not different from in NT, suggesting that the regulation of Skp2 in NSCLC by miR-3163 may require coordination of Meg3 |
| Pubmed ID | 26482610 |
| Year | 2015 |
| Title | Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163 |
| External Links |
| Links for Skp2 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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