Detail
| LncRNA Name | BC087858 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay, Cell apoptosis assay etc. |
| Sample | NSCLC tissues, cell lines (PC9, H1975, H460 and H23) |
| Expression Pattern | up-regulated |
| Function Description | Over-expression was observed in NSCLC cells and patients with acquired resistance to EGFR-TKIs and significantly associated with a shorter progression-free survival (PFS) in tumors with respond to EGFR-TKIs. The significant relationship was not observed in patients with T790M mutation but in patients with non-T790M. Down-regulation of BC087858 could significantly promote PC9/R and PC9/G2 cells invasion. BC087858 knockdown restored gefitinib sensitivity in acquired resistant cells with non-T790M and inhibited the activation of the PI3K/AKT and MEK/ERK pathways and epithelial-mesenchymal transition (EMT) via up-regulating ZEB1 and Snail. |
| Pubmed ID | 27409677 |
| Year | 2016 |
| Title | Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer. |
| External Links |
| Links for BC087858 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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