Detail
| LncRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 Sequence |
| Ensembl | ENSG00000255717 |
| RefSeq | NR_003098 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (HEK293T , N69, CNE,HNE-1), NPC tissues |
| Expression Pattern | up-regulated |
| Function Description | Down-regulation of SNHG1 facilitated the expression of miR-145-5p and further suppressed the level of NAUK1 in CNE and HNE-1 cells. Silencing of SNHG1, up-regulation of miR-145-5p and inhibition of NAUK1 by relative transfection all attenuated the aggressiveness of CNE and HNE-1 cells both in vivo and in vitro. Moreover, the impaired cell migration and invasion by SNHG1 siRNA could be rescued by cotransfection of miR-145-5p in CNE and HNE-1 cells. LncRNA SNHG1 promoted the expression of NUAK1 by down-regulating miR-145-5p and thus promoted the aggressiveness of nasopharyngeal carcinoma cells through AKT signalling pathway and induced epithelial-mesenchymal transition (EMT). |
| Pubmed ID | 29575772 |
| Year | 2018 |
| Title | LncRNA SNHG1 functions as a ceRNA to antagonize the effect of miR-145a-5p on the down-regulation of NUAK1 in nasopharyngeal carcinoma cell |
| External Links |
| Links for SNHG1 | GenBank HGNC lncrnadb Noncode |
| Links for nasopharyngeal cancer | Omim Cosmic |
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