SNHG1 expression was measured in glioma tissues and cell lines.The association between SNHG1 expression in tissues and clinicopathological characteristics and prognosis in glioma patients was also explored. SNHG1 was highly expressed in glioma tissues, and its upregulation was closely related to old age.ectopic expression of SNHG1 enhanced cell proliferation and cell invasion and reduced cell apoptosis in vitro, while SNHG1 knockdown reversed these effects. High expression of SNHG1 correlates with large tumor size, poor differentiation, aggressive BCLC stage and poor prognosis of HCC patients. High expression of SNHG1 also exacerbates HCC cell proliferation, invasion, and migration in vitro via suppression of miR-195 and p53.SNHG1 promoted cell proliferation via proto-oncogene CST3 upregulation by acting as a non-degradable sponge for the tumor suppressor miR-338 in esophageal cancer cells.