Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name SNHG1
   Synonyms SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16
   Region GRCh38_11:62851988-62855914    Sequence
   Ensembl ENSG00000255717
   RefSeq NR_003098
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colon cancer
   ICD-0-3 C18  
   Methods qPCR, Western blot etc.
   Sample colon cancer tissues, cell lines (HCT-116, Caco-2 and HT-29)
   Expression Pattern up-regulated
   Function Description

Cell functional experiments were performed after knockdown of SNHG1, including Cell Counting Kit-8 assay, colony formation assay, Transwell assay, and flow cytometric analyses of cell apoptosis, which suggested that SNHG1 stimulated colon cancer cell proliferation, promoted cell invasion and migration, and inhibited apoptosis. Immunohistochemical staining and western blotting experiments revealed that in colon cancer cells with SNHG1 knockdown, B-catenin, c-Myc and cyclin D1 protein levels were decreased, while E-cadherin was increased, which suggested that SNHG1 promoted colon cancer cell proliferation, migration and invasion through the Wnt/B-catenin signaling pathway. Our results indicated that SNHG1 and its interrelated components may be future therapeutic targets of carcinoma of the colon.

   Pubmed ID 29749530
   Year 2018
   Title Long non-coding RNA SNHG1 predicts a poor prognosis and promotes colon cancer tumorigenesis.
   External Links
   Links for  SNHG1 GenBank       HGNC       lncrnadb       Noncode
   Links for  colon cancer Omim       Cosmic

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