Detail
| LncRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 Sequence |
| Ensembl | ENSG00000255717 |
| RefSeq | NR_003098 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | NSCLC cell lines (H358, H1299, A549, and SK-MES-1), bronchial epithelial cell line (HBE) |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 directly bound to microRNA (miRNA)-145-5p,isolating miR-145-5p from its target gene MTDH.Inhibition of SNHG1 suppressed NSCLC cell viability, proliferation,migration, and invasion in vitro, but its effect was rescued by miR-145-5p inhibition. These results demonstrate that SNHG1 contributes to NSCLC progression by modulating the miR-145-5p/ MTDH axis, and it could potentially be a therapeutic target as well as a diagnostic marker. |
| Pubmed ID | 29466052 |
| Year | 2018 |
| Title | Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p. |
| External Links |
| Links for SNHG1 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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