Detail
| LncRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 Sequence |
| Ensembl | ENSG00000197989 |
| RefSeq | NR_024127 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | Microarray, qPCR, Western blot, in vitro knockdown, RIP |
| Sample | cell lines (U87, U251), glioma tissues |
| Expression Pattern | up-regulated |
| Function Description | Long non-coding RNA (lncRNA) dysregulation is involved in tumorigenesis and regulation of diverse cellular processes in gliomas.SNHG12 significantly inhibited malignant biological behaviors of glioma cells. miR-195, downregulated in glioma tissues and cells, significantly impaired the malignant progression of glioma cells.TDP43 upregulated miR-195 in an SNHG12-dependent manner. SNHG12 and miR-195 were in an RNA-induced silencing complex (RISC).Inhibition of SNHG12 combined with restoration of miR-195 robustly reduced tumor growth in vivo. SOX5 was overexpressed in glioma tissues and cells.miR-195 targeted SOX5 3' UTR in a sequence-specific manner. Gelsolin was activated by SOX5. More importantly, SOX5 activated SNHG12 promoter and upregulated its expression, forming a feedback loop. |
| Pubmed ID | 29499929 |
| Year | 2017 |
| Title | Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells. |
| External Links |
| Links for SNHG12 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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