Detail
| LncRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 Sequence |
| Ensembl | ENSG00000197989 |
| RefSeq | NR_024127 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | HCC tissues, cell line (SK-Hep1) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was significantly higher in the HCC tissues than that in the adjacent normal tissues.There were direct interactions between miR-199a/b-5p and the binding site of SNHG12.SNHG12 functioned as an endogenous sponge for miR-199a/b-5p to regulate the expression of MLK3 and affect the NF-kB pathway. |
| Pubmed ID | 28073380 |
| Year | 2017 |
| Title | Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma. |
| External Links |
| Links for SNHG12 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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