Detail
| LncRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 Sequence |
| Ensembl | ENSG00000197989 |
| RefSeq | NR_024127 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | TNBC tissues, cell lines (MDA-MB-231 and BT-549) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 is upregulated in TNBC. Mechanistic investigations show that SNHG12 is a direct transcriptional target of c-MYC. Silencing SNHG12 expression inhibits TNBC cells proliferation and apoptosis promotion, whereas SNHG12 overexpression has the opposite effect. In addition, we reveal that SNHG12 may promote cells migration by regulating MMP13 expression. |
| Pubmed ID | 28337281 |
| Year | 2017 |
| Title | C-MYC-induced upregulation of lncRNA SNHG12 regulates cell proliferation, apoptosis and migration in triple-negative breast cancer. |
| External Links |
| Links for SNHG12 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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