Detail
| LncRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 Sequence |
| Ensembl | ENSG00000197989 |
| RefSeq | NR_024127 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | osteosarcoma tissues, osteosarcoma cell lines (143B, U2OS, MG63 and HOS) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was significantly upregulated in both osteosarcoma tissues and cell lines and osteosarcoma patients with high levels of SNHG12 tended to have a poor prognosis. Dual-luciferase reporter and RIP assays were conducted to confirm that SNHG12 functioned as a ceRNA, modulating the expression of Notch2 by sponging miR-195-5p in osteosarcoma. |
| Pubmed ID | 29229388 |
| Year | 2017 |
| Title | LncRNA SNHG12 promotes tumorigenesis and metastasis in osteosarcoma by upregulating Notch2 by sponging miR-195-5p. |
| External Links |
| Links for SNHG12 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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