Detail
| LncRNA Name | SNHG14 |
| Synonyms | NCRNA00214, UBE3A-AS |
| Region | GRCh38_15:24978583-25419462 Sequence |
| Ensembl | ENSG00000224078 |
| RefSeq | NR_146177 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | glioma tissues, glioma cell lines (U251 and U87) |
| Expression Pattern | down-regulated |
| Function Description | SNHG14 was found to be downregulated in human glioma tissues and cell lines. there was a negative correlation between SNHG14 expression and miR-92a-3p expression.miR-92a-3p could directly bind to SNHG14. miR-92a-3p was significantly upregulated in glioma and acted as an oncogene in glioma cells by inhibiting Bim. Moreover, mechanistic investigations showed that miR-92a-3p could reverse the tumour suppressive effects induced by SNHG14 in glioma, indicating that SNHG14 may act as an endogenous sponge that competes for binding to miR-92a-3p. |
| Pubmed ID | 29552296 |
| Year | 2018 |
| Title | The long non-coding RNA SNHG14 inhibits cell proliferation and invasion and promotes apoptosis by sponging miR-92a-3p in glioma. |
| External Links |
| Links for SNHG14 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.