Detail
| LncRNA Name | SNHG14 |
| Synonyms | NCRNA00214, UBE3A-AS |
| Region | GRCh38_15:24978583-25419462 Sequence |
| Ensembl | ENSG00000224078 |
| RefSeq | NR_146177 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C64.9 M8005/0 |
| Methods | qRT-PCR ect. |
| Sample | breast cancer cell lines ( SKBR-3 and BT474) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA?SNHG14 may promote the effect of trastuzumab by targeting the apoptosis regulator Bcl?2 (Bcl?2)/apoptosis regulator BAX (Bax) signaling pathway. Furthermore, the expression level of serum exosomal lncRNA?SNHG14 was upregulated in patients who exhibited resistance to trastuzumab, compared with patients exhibiting a response. |
| Pubmed ID | 30015837 |
| Year | 2018 |
| Title | Exosome-mediated transfer of lncRNA?SNHG14 promotes trastuzumab chemoresistance in breast cancer. |
| External Links |
| Links for SNHG14 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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