Detail
| LncRNA Name | SNHG15 |
| Synonyms | SNHG15, C7orf40, Linc-Myo1g, MYO1GUT, FLJ38860, Linc-Myo1g |
| Region | GRCh38_7:44983023-44986961 Sequence |
| Ensembl | ENSG00000232956 |
| RefSeq | NR_003697 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-PC, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | Primary cancer tissues, breast cancer cell lines (MCF-7, BT-20, ZR-75-1, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | SNHG15 downregulation suppressed cell migration and invasion in MCF-7 and BT-20 cells, and inhibited epithelial-mesenchymal transition (EMT).In mechanism, we found that SNHG15 acted as a competing endogenous RNA to sponge miR-211-3p,which was downregulated in breast cancers and inhibited cell proliferation and migration. Our results showed that there was a negative correlation between SNHG15 and miR-211-3p expression in breast cancer patients. |
| Pubmed ID | 29217194 |
| Year | 2017 |
| Title | Long noncoding RNA SNHG15 promotes human breast cancer proliferation, migration and invasion by sponging miR-211-3p. |
| External Links |
| Links for SNHG15 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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