Detail
| LncRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 Sequence |
| Ensembl | ENSG00000163597 |
| RefSeq | NR_038108 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7, MDA-MB-468 and HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Expression levels of SNHG16 were found to be frequently higher in breast cancer tissues than in the paired noncancerous tissues.Gain- and loss-of-function studies proved that SNHG16 significantly promoted breast cancer cell migration. In addition, we identified a positive correlation between SNHG16 and E2F5 in breast cancer tissues. Furthermore,we demonstrated that forced expression of miR-98 could partially abrogate SNHG16-mediated increase of breast cancer cells migration,suggesting that SNHG16 promoted cell migration in a miR-98 dependent manner. |
| Pubmed ID | 28232182 |
| Year | 2017 |
| Title | SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. |
| External Links |
| Links for SNHG16 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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