Detail
| LncRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 Sequence |
| Ensembl | ENSG00000163597 |
| RefSeq | NR_038108 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, Flow Cytometry, Luciferase Assay, etc. |
| Sample | ESCC tissues, cell lines (TE-13, TE-1,EC-1, Eca-109, HEEC) |
| Expression Pattern | up-regulated |
| Function Description | Kaplan-Meier assay showed that the survival time of patients with high SNHG16 expression was significantly shorter than those with low SNHG16 expression (p = 0.0017). Loss-of-function experiments revealed that knockdown of SNHG16 suppressed proliferation and invasion and induced apoptosis of ESCC cells. Mechanistically, Wnt/B-catenin signaling pathways were actively modulated by SNHG16 in ESCC cells. |
| Pubmed ID | 29949155 |
| Year | 2018 |
| Title | LncRNA SNHG16 predicts poor prognosis in ESCC and promotes cell proliferation and invasion by regulating Wnt/β-catenin signaling pathway. |
| External Links |
| Links for SNHG16 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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