Detail
| LncRNA Name | SNHG20 |
| Synonyms | SNHG20, C17orf86, LINC00338, NCRNA00338, SCARNA16HG, PRO0872, FLJ25582, DKFZp686L05235 |
| Region | GRCh38_17:77086716-77094990 Sequence |
| Ensembl | ENSG00000234912 |
| RefSeq | NR_027058 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR etc. |
| Sample | cervical cancer tissue, cell lines (HeLa, SiHa, C33A, SW756, and ME-180) |
| Expression Pattern | up-regulated |
| Function Description | SNHG20 expression was significantly increased in cervical cancer. MiR-140-5p acted as a downstream target of SNHG20. SNHG20 inhibition or miR-140-5p overexpression reduced cervical cancer cells proliferation and invasion ability. Furthermore, we identified that ADAM10 could act as a potential target of miR-140-5p. MEK/ERK signaling could be inhibited by miR-140-5p mimics in cervical cancer cells. In addition, ADAM10 overexpression abrogated the effect of miR-140-5p mimics on cervical cancer cells proliferation and invasion. |
| Pubmed ID | 29604594 |
| Year | 2018 |
| Title | LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer. |
| External Links |
| Links for SNHG20 | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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