Detail
| LncRNA Name | SNHG20 |
| Synonyms | SNHG20, C17orf86, LINC00338, NCRNA00338, SCARNA16HG, PRO0872, FLJ25582, DKFZp686L05235 |
| Region | GRCh38_17:77086716-77094990 Sequence |
| Ensembl | ENSG00000234912 |
| RefSeq | NR_027058 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer cell lines (Bgastric cancer823, Sgastric cancer-7901, MKN45), hepatocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Thus, the results showed that SNHG20 acted as an oncogene in GC and targeting SNHG20 may serve as a therapeutic target for GC. The western-blotting results showed that knockdown of SNHG20 significantly inhibited the expression levels of transcription factor Twist1 and EMT maker Vimentin, but upregulating the E-cadherin expression in MKN45 cells.LncRNAs could regulated cancer cells phenotypes through regulating target gene expression by different mechanisms, including chromatin modification, genomic imprinting, RNA decay and sponging miRNAs [20]. |
| Pubmed ID | 29113337 |
| Year | 2017 |
| Title | Long noncoding RNA SNHG20 promotes gastric cancer progression by inhibiting p21 expression and regulating the GSK-3B/ B-catenin signaling pathway. |
| External Links |
| Links for SNHG20 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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