Detail
| LncRNA Name | SNHG20 |
| Synonyms | SNHG20, C17orf86, LINC00338, NCRNA00338, SCARNA16HG, PRO0872, FLJ25582, DKFZp686L05235 |
| Region | GRCh38_17:77086716-77094990 Sequence |
| Ensembl | ENSG00000234912 |
| RefSeq | NR_027058 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, RIP, CCK-8 assay etc. |
| Sample | HCC tissues, cell lines (MHCC97L, SMCC-7721, MHCC97H and Huh-7) |
| Expression Pattern | up-regulated |
| Function Description | SNHG20 was significantly up-regulated in HCC tissues. In vitro, loss-function assays revealed that knockdown of SNHG20 inhibited cell proliferation and invasion, whereas, gain-of-function promoted cell proliferation and invasion. Furthermore, knockdown of SNHG20 inhibited ZEB1, ZEB2, N-cadherin and Vimentin expression and up-regulated the E-cadherin expression in HCC cells. Mechanistic investigation revealed that SNHG20 could bind to enhancer of zeste homolog 2 (EZH2) and regulated E-cadherin expression. |
| Pubmed ID | 28282787 |
| Year | 2017 |
| Title | Long non-coding RNA SNHG20 predicts a poor prognosis for HCC and promotes cell invasion by regulating the epithelial-to-mesenchymal transition. |
| External Links |
| Links for SNHG20 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.