Detail
| LncRNA Name | SNHG3 |
| Synonyms | SNHG3, NCRNA00014, RNU17C, RNU17D, U17HG, U17HG-A, U17HG-AB, NCRNA00014 |
| Region | GRCh38_1:28505980-28510892 Sequence |
| Ensembl | ENSG00000242125 |
| RefSeq | NR_002909.1 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot |
| Sample | Human colorectal cancer cell lines (HT29, HCT116, SW480, LoVo) |
| Expression Pattern | up-regulated |
| Function Description | SNHG3 promoted CRC progression via sponging miR-182-5p and upregulating c-Myc and its target genes.The results confirmed that SNHG3 was markedly upregulated in CRC.Notably, Kaplan-Meier analysis and log-rank test demonstrated that patients with overexpression of SNHG3 had poorer overall survival time than those with low expression of SNHG3.HOTAIR expression levels were significantly positively correlated with hepatocellular carcinoma (HCC) recurrence and metastasis and with the overall survival time of patients with HCC. |
| Pubmed ID | 28731158 |
| Year | 2017 |
| Title | The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. |
| External Links |
| Links for SNHG3 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.