Detail
| LncRNA Name | SNHG5 |
| Synonyms | SNHG5, C6orf160, LINC00044, U50HG, bA33E24.2, MGC16362, bA33E24.2, U50HG, NCRNA00044 |
| Region | GRCh38_6:85660950-85678736 Sequence |
| Ensembl | ENSG00000203875 |
| RefSeq | NR_003038 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Northern blot, RIP, Luciferase reporter assay etc. |
| Sample | cell lines (HCT116, LS174T, HT-29) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in vitro and limits tumour outgrowth in vivo, whereas SNHG5 overexpression counteracts oxaliplatin-induced apoptosis. |
| Pubmed ID | 28004750 |
| Year | 2016 |
| Title | SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. |
| External Links |
| Links for SNHG5 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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