Detail
| LncRNA Name | SNHG5 |
| Synonyms | SNHG5, C6orf160, LINC00044, U50HG, bA33E24.2, MGC16362, bA33E24.2, U50HG, NCRNA00044 |
| Region | GRCh38_6:85660950-85678736 Sequence |
| Ensembl | ENSG00000203875 |
| RefSeq | NR_003038 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | Western blot, in vitro knockdown, Luciferase reporter assay, RNAi etc. |
| Sample | cell line (PC9, A549, HEK-293T), lung adenocarcinoma tissues |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of SNHG5 suppressed the expression of miR-377, while the knockdown of SNHG5 increased the miR-377 expression. MiR-377 expression was significantly upregulated in LAD specimens with acquired gefitinib resistance and was negatively correlated with SNHG5 expression. In addition, CASP1 was predicted as a downstream target of miR-377.Knockdown of CASP1 in SNHG5-overexpression PC9GR cells abolished their gefitinib resistance. |
| Pubmed ID | 29592872 |
| Year | 2018 |
| Title | The long non-coding RNA SNHG5 regulates gefitinib resistance in lung adenocarcinoma cells by targeting miR-377/CASP1 axis. |
| External Links |
| Links for SNHG5 | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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