Detail
| LncRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 Sequence |
| Ensembl | ENSG00000245910 |
| RefSeq | NR_002599 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | gastric tumor tissue, cell lines (MGC-803, AGS, SGC-7901, BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | SNHG6 was overexpressed in gastric cancer tissues and cell lines.In summary,our findings demonstrated that SNHG6 acted as an oncogene in gastric cancer cells through regulating miR-101-3p/ZEB1 at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p27. High expression levels of SNHG6 wereassociated with invasion depth, lymph node metastasis, distant metastasis and tumor/node/metastasis (TNM) stage, and predicted poor prognosis. |
| Pubmed ID | 28683446 |
| Year | 2017 |
| Title | LncRNA SNHG6 is Associated with Poor Prognosis of Gastric Cancer and Promotes Cell Proliferation and EMT through Epigenetically Silencing p27 and Sponging miR-101-3p |
| External Links |
| Links for SNHG6 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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