Detail
| LncRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 Sequence |
| Ensembl | ENSG00000245910 |
| RefSeq | NR_002599 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, western blot, RIP etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (hepatocellular carcinoma C22.0 M8170/3) |
| Expression Pattern | differential expression |
| Function Description | Additionally, SNHG6 promoted expression of MAT2A by suppressing direct binding of miR-1297 to the MAT2A 3'UTR. SNHG6 regulated steady-state SAMe levels via coupling of two miR-1297-mediated SAMe-dependent positive feedback loops. Interestingly, the effect of SNHG6 on genome-wide methylation was inhibited by exogenous SAMe within a certain concentration range. |
| Pubmed ID | 29844127 |
| Year | 2018 |
| Title | SNHG6 Acts as a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-Mediated S-Adenosylmethionine-Dependent Positive Feedback Loops |
| External Links |
| Links for SNHG6 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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