Detail
| LncRNA Name | SNHG7 |
| Synonyms | SNHG7, NCRNA00061, MGC16037 |
| Region | GRCh38_9:136721366-136728184 Sequence |
| Ensembl | ENSG00000233016 |
| RefSeq | NR_003672 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | Glioblastoma tissue, human GBM cell lines (A172, U87, T98G and SHG44) |
| Expression Pattern | up-regulated |
| Function Description | the expression of SNHG7 was significantly upregulated in GBM tissues and cell lines compared with non-cancerous brain tissues. Furthermore,SNHG7 knockdown remarkably suppressed the proliferation, migration and invasion of A172 and U87-cells while inducing their apoptosis. Subsequently, SNHG7 knockdown significantly inhibited tumor growth and metastasis in-vivo by using xenograft experiments in nude mice.SNHG7 directly inhibited miR-5095,which targeted the 3'UTR of CTNNB1 mRNA and subsequently downregulated the Wnt/B-catenin signaling pathway in GBM. Using rescue experiments, we demonstrated that SNHG7 promoted the proliferation, migration and invasion of GBM cells through the inhibition of miR-5095 and concomitant activation of Wnt/B-catenin signaling pathway. |
| Pubmed ID | 29360452 |
| Year | 2018 |
| Title | Long noncoding RNA SNHG7 promotes the progression and growth of glioblastoma via inhibition of miR-5095. |
| External Links |
| Links for SNHG7 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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