Detail
| LncRNA Name | SNHG7 |
| Synonyms | SNHG7, NCRNA00061, MGC16037 |
| Region | GRCh38_9:136721366-136728184 Sequence |
| Ensembl | ENSG00000233016 |
| RefSeq | NR_003672 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, RIP, Luciferase reporter assay, Western blot, etc. |
| Sample | CRC cell lines (caco2, SW480, SW620, Hct116, LoVo). human normal colon epithelial cell line (FHC). CRC tissues, adjacent tissues. |
| Expression Pattern | down-regulation |
| Function Description | SNHG7 expression showed a high fold (SW620/SW480) in CRC microarrays. The CRC patients with high expression of SNHG7 had a significantly poor prognosis. Furthermore, SNHG7 promoted CRC cell proliferation, metastasis, mediated cell cycle, and inhibited apoptosis. SNHG7 and GALNT7 were observed for co-expression by CNC analysis, and a negative correlation of SNHG7 and miR-34a were found by competing endogenous RNA (ceRNA) analysis. The CRC-related SNHG7 and miR-34a might be implicated in CRC progression via GALNT7, suggesting the potential usage of SNHG7/miR-34a/GALNT7 axis in CRC treatment.The survival curves were calculated using the Kaplan-Meier method, and the differences were assessed by a log-rank test. |
| Pubmed ID | 29970122 |
| Year | 2018 |
| Title | Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression. |
| External Links |
| Links for SNHG7 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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