Detail
| LncRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT, DKFZp761J1324 |
| Region | GRCh38_3:180989762-181836880 Sequence |
| Ensembl | ENSG00000242808 |
| RefSeq | NR_004053 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | qPCR, Western blot, in vitro knockdown, Luciferase reporter assay etc. |
| Sample | cell lines (U87, U251) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of SOX2OT significantly increased the expression of miR-194-5p and miR-122 in GSCs.SOX2OT bound to both miR-194-5p and miR-122. SOX3 and TDGF-1 were up-regulated in human glioma tissues and GSCs. Knockdown of SOX3 inhibited the proliferation, migration and invasion of GSCs, promoted GSCs apoptosis, and decreased TDGF-1 mRNA and protein expression through direct binding to the TDGF-1 promoter. Over-expression of miR-194-5p and miR-122 decreased the mRNA and protein expression of SOX3 by targeting its 3â??UTR. Furthermore, SOX3 knockdown also inhibited the SOX2OT expression through direct binding to the SOX2OT promoter and formed a positive feedback loop. |
| Pubmed ID | 29132362 |
| Year | 2017 |
| Title | Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122 |
| External Links |
| Links for SOX2OT | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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