Detail
| LncRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT, DKFZp761J1324 |
| Region | GRCh38_3:180989762-181836880 Sequence |
| Ensembl | ENSG00000242808 |
| RefSeq | NR_004053 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western Blot etc. |
| Sample | cell lines (Saos-2, MG-63, U-2 OS, MNNG/HOS) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA SOX2-OT expression was increased in osteosarcoma tissues and cell lines, and associated with malignant status and overall survival in osteosarcoma patients. LncRNA SOX2-OT positively regulated SOX2 expression in osteosarcoma cells and positively associated with SOX2 expression in osteosarcoma tissues. The rescued-function studies suggested that SOX2 is necessary for lncRNA SOX2-OT induced osteosarcoma cells migration, invasion, and expression of cancer stem cell biomarkers. In conclusion, lncRNA SOX2-OT is a prognostic biomarker for osteosarcoma patients and serves an oncogenic role to regulate osteosarcoma cells migration, invasion, and expression of cancer stem cell biomarkers. |
| Pubmed ID | 28960757 |
| Year | 2017 |
| Title | LncRNA SOX2-OT Is a Novel Prognostic Biomarker for Osteosarcoma Patients and Regulates Osteosarcoma Cells Proliferation and Motility Through Modulating SOX2 |
| External Links |
| Links for SOX2OT | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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