Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name SOX2OT
   Synonyms SOX2-OT, NCRNA00043, SOX2OT, DKFZp761J1324
   Region GRCh38_3:180989762-181836880    Sequence
   Ensembl ENSG00000242808
   RefSeq NR_004053
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name lung squamous cell carcinoma
   ICD-0-3 C34  M8070/3
   Methods qPCR etc.
   Sample LSCC tissues
   Expression Pattern up-regulated
   Function Description

In conclusion, eight out of the nine tested genes were recurrently over-expressed, but SOX2 and SOX2OT were the most consistently highly over-expressed and thus are the best candidates to be driver genes of 3q26.3 amplifications.

   Pubmed ID 20126410
   Year 2010
   Title SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas.
   External Links
   Links for  SOX2OT GenBank       HGNC       lncrnadb       Noncode
   Links for  lung squamous cell carcinoma Omim       Cosmic

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