Detail
| LncRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT, DKFZp761J1324 |
| Region | GRCh38_3:180989762-181836880 Sequence |
| Ensembl | ENSG00000242808 |
| RefSeq | NR_004053 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, RNAi, Flow cytometry assay etc. |
| Sample | NSCLC tissues, cell lines (A549, U-87 MG) |
| Expression Pattern | up-regulated |
| Function Description | Our data revealed that SOX2OT variants 4 and 7 were upregulated around six times in lung tumor tissues, compared to their non-tumor counterparts. The SOX2OT knockdown significantly reduced the colony formation ability of cancer cells; however, no alterations in the rate of apoptosis were detected. On the other hand, SOX2OT-suppressed cells had elevated accumulation in G2/M phase of cell cycle and exhibited limited mobility. |
| Pubmed ID | 26846097 |
| Year | 2016 |
| Title | Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer. |
| External Links |
| Links for SOX2OT | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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