Detail
| LncRNA Name | SOX2OT |
| Synonyms | SOX2-OT, NCRNA00043, SOX2OT, DKFZp761J1324 |
| Region | GRCh38_3:180989762-181836880 Sequence |
| Ensembl | ENSG00000242808 |
| RefSeq | NR_004053 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (MCF10A) |
| Expression Pattern | up-regulated |
| Function Description | The expression of SOX2 and SOX2OT is concordant in breast cancer, differentially expressed in estrogen receptor positive and negative breast cancer samples and that both are up-regulated in suspension culture conditions that favor growth of stem cell phenotypes. Importantly, ectopic expression of SOX2OT led to an almost 20-fold increase in SOX2 expression, together with a reduced proliferation and increased breast cancer cell anchorage-independent growth. |
| Pubmed ID | 25006803 |
| Year | 2014 |
| Title | Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer. |
| External Links |
| Links for SOX2OT | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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