Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name SPRY4-IT1
   Synonyms SPRY4-IT1, SPRIGHTLY
   Region NA    Sequence
   Ensembl ENSG00000281881
   RefSeq NR_131221
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name osteosarcoma
   ICD-0-3  M9180/3
   Methods qPCR, Western blot
   Sample osteosarcoma tumor tissues
   Expression Pattern up-regulated
   Function Description

Our result showed that SPRY4-IT1 was upregulated in OS tissues. Further experiments revealed that SPRY4-IT1 knockdown significantly inhibited OS cells proliferation by causing G1 arrest and promoting apoptosis.

   Pubmed ID 28078006
   Year 2016
   Title Effects of long non-coding RNA SPRY4-IT1 on osteosarcoma cell biological behavior
   External Links
   Links for  SPRY4-IT1 GenBank       HGNC       lncrnadb       Noncode
   Links for  osteosarcoma Omim       Cosmic

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