Detail
| LncRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA Sequence |
| Ensembl | ENSG00000281881 |
| RefSeq | NR_131221 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot |
| Sample | TC tissues, thyroid squamous cell carcinoma cell line (SW579), papillary TC cell lines (K1 and TPC-1) |
| Expression Pattern | up-regulated |
| Function Description | the level of SPRY4-IT1 was significantly upregulated in TC tissues and cell lines, which was correlated with poor prognosis. And cellular experiments exhibited that silenced SPRY4-IT1 inhibited the proliferative and migratory abilities of TC cells. Mechanism assays noted that silenced SPRY4-IT1 could increase the levels of transforming growth factor-B1 (TGF-B1) and p-Smad2/3 and function mediated by si-SPRY4-IT1 could be rescued by the interference of TGF-B1. |
| Pubmed ID | 29234152 |
| Year | 2017 |
| Title | LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer. |
| External Links |
| Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for thyroid cancer | Omim Cosmic |
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