Detail
LncRNA Name | SPRY4-IT1 |
Synonyms | SPRY4-IT1, SPRIGHTLY |
Region | NA Sequence |
Ensembl | ENSG00000281881 |
RefSeq | NR_131221 |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | testicular germ cell tumor |
ICD-0-3 | C62 M9065/3 |
Methods | qPCR, Western blot, in vitro knockdown |
Sample | TGCT tissues, TGCT cell lines (NT2-D1 and 833 K) |
Expression Pattern | up-regulated |
Function Description | We found higher expression levels of SPRY4, both mRNA and protein, and of SPRY4-IT1 in human TGCT than in normal adult testis. Small-interfering RNA (siRNA)-mediated transient knockdown of SPRY4 and SPRY4-IT1 in two TGCT cell lines 833-K and NT2-D1 resulted in decreased cell growth, migration, and invasion. Knockdown of SPRY4 and SPRY4-IT1 also led to a significant reduction in the phosphorylation of Akt. Our findings indicate that SPRY4 and SPRY4-IT1 may act as oncogenes in TGCTs via activation of the PI3K / Akt signalling pathway. |
Pubmed ID | 29410498 |
Year | 2018 |
Title | Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours. |
External Links |
Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
Links for testicular germ cell tumor | Omim Cosmic |
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