Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name SPRY4-IT1
   Synonyms SPRY4-IT1, SPRIGHTLY
   Region NA    Sequence
   Ensembl ENSG00000281881
   RefSeq NR_131221
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name testicular germ cell tumor
   ICD-0-3 C62  M9065/3
   Methods qPCR, Western blot, in vitro knockdown
   Sample TGCT tissues, TGCT cell lines (NT2-D1 and 833 K)
   Expression Pattern up-regulated
   Function Description

We found higher expression levels of SPRY4, both mRNA and protein, and of SPRY4-IT1 in human TGCT than in normal adult testis. Small-interfering RNA (siRNA)-mediated transient knockdown of SPRY4 and SPRY4-IT1 in two TGCT cell lines 833-K and NT2-D1 resulted in decreased cell growth, migration, and invasion. Knockdown of SPRY4 and SPRY4-IT1 also led to a significant reduction in the phosphorylation of Akt. Our findings indicate that SPRY4 and SPRY4-IT1 may act as oncogenes in TGCTs via activation of the PI3K / Akt signalling pathway.

   Pubmed ID 29410498
   Year 2018
   Title Knockdown of SPRY4 and SPRY4-IT1 inhibits cell growth and phosphorylation of Akt in human testicular germ cell tumours.
   External Links
   Links for  SPRY4-IT1 GenBank       HGNC       lncrnadb       Noncode
   Links for  testicular germ cell tumor Omim       Cosmic

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