Detail
| LncRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA Sequence |
| Ensembl | ENSG00000281881 |
| RefSeq | NR_131221 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | microarray, qPCR, RNAi, Western blot etc. |
| Sample | breast cancer tissues, cell lines (MD-MB-231, MD-MB-435S, MCF-10A, MCF-7 etc.) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 expression was significantly upregulated in 48 breast cancer tumor tissues comparedwith normal tissues. Additionally, increased SPRY4-IT1 expression was found to be associated with a larger tumor size and an advanced pathological stage in breast cancer patients. SPRY4-IT1 is a novel prognostic biomarker and a potential therapeutic candidate for breast cancer. |
| Pubmed ID | 25742952 |
| Year | 2015 |
| Title | The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. |
| External Links |
| Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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