Detail
| LncRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA Sequence |
| Ensembl | ENSG00000281881 |
| RefSeq | NR_131221 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, Cell cycle assay, Cell apoptosis assay etc. |
| Sample | bladder cancer tissues, cell lines (EJ, UMUC3, T24T) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 knockdown induced inhibition of cell proliferation, cell migration and invasion ability,and caused promotion of apoptosis in bladder cancer both in vitro and in vivo.Mechanistically, knockdown of SPRY4-IT1 increased the expression of miR-101-3p and subsequently inhibited the expression of EZH2 at posttranscriptional level. Importantly, SPRY4-IT1 could directly interact with miR-101-3p and down-regulation of miR-101-3p efficiently reversed the suppression of EZH2 induced by SPRY4-IT1 shRNA. Thus, SPRY4-IT1 positively regulated the expression of EZH2 through sponging miR-101-3p, and played an oncogenic role in bladder cancer progression. |
| Pubmed ID | 27998761 |
| Year | 2017 |
| Title | LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2. |
| External Links |
| Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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