Detail
| LncRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA Sequence |
| Ensembl | ENSG00000281881 |
| RefSeq | NR_131221 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot |
| Sample | hepatocellular carcinoma tissues, cell lines (MHCC97L, MHCC97H, HepG2 and SMMC7721, HL7702) |
| Expression Pattern | up-regulated |
| Function Description | high expression of SPRY4-IT1 was associated with poor 5-year overall survival in the HCC patient cohort.the expression of SPRY4-IT1 was significantly correlated with TNM stage in HCC patients. knock-down of SPRY4-IT1 suppressed cell proliferation, colony formation, cell invasion and migration in HCC cells.knock-down of SPRY4-IT1 induced cell cycle arrest at G0/G1 phase and induced apoptosis. knock-down of SPRY4-IT1 also suppressed the mRNA and protein expression of estrogen-related receptor a (ERRa).knock-down of ERRa inhibited cell proliferation, colony formation, cell invasion and migration in HCC cells. More importantly, ERRa overexpression antagonized the effects of SPRY4-IT1 knock-down on cell proliferation, colony formation, cell invasion and migration in HCC cells. |
| Pubmed ID | 29214989 |
| Year | 2017 |
| Title | Long non-coding RNA SPRY4-IT1 promotes development of hepatic cellular carcinoma by interacting with ERRa and predicts poor prognosis. |
| External Links |
| Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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