Detail
| LncRNA Name | SPRY4-IT1 |
| Synonyms | SPRY4-IT1, SPRIGHTLY |
| Region | NA Sequence |
| Ensembl | ENSG00000281881 |
| RefSeq | NR_131221 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | colorectal carcinoma tissues, cell lines (LoVo, RKO, SW620 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | SPRY4-IT1 was upregulated in human primary colorectal carcinoma tissues.Knockdown of SPRY4-IT1 inhibited colorectal carcinoma cell proliferation,migration,and invasion.Moreover,we confirmed that the expression of epithelial-mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. SPRY4-IT1 could negatively regulate the expression of miR-101-3p in colorectal carcinoma cells.The bioinformatics prediction revealed putative miR-101-3p binding sites within SPRY4-IT1 transcripts. |
| Pubmed ID | 28720069 |
| Year | 2018 |
| Title | Long non-coding RNA SPRY4-IT1 promotes proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells. |
| External Links |
| Links for SPRY4-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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