Detail
| LncRNA Name | SRA1 |
| Synonyms | SRA1, SRA, SRAP, STRAA1, pp7684 |
| Region | GRCh38_5:140537340-140558252 Sequence |
| Ensembl | ENSG00000213523 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | cell lines (BT-20, MDA-MB-469, MDA-MB-231 etc.) |
| Expression Pattern | differential expression |
| Function Description | We recently reported a decreased estrogen receptor activity in breast cancer cells overexpressing SRAP, suggesting antagonist roles played by SRA1 RNA and SRAP. The primary genomic sequence in and around intron-1 is sufficient to lead to a differential splicing of this intron. We propose that alternative splicing of intron-1 is one mechanism used by breast cancer cells to regulate the balance between coding and functional noncoding SRA1 RNAs. |
| Pubmed ID | 16848684 |
| Year | 2006 |
| Title | Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines. |
| External Links |
| Links for SRA1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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