Detail
LncRNA Name | SRA1 |
Synonyms | SRA1, SRA, SRAP, STRAA1, pp7684 |
Region | GRCh38_5:140537340-140558252 Sequence |
Ensembl | ENSG00000213523 |
RefSeq | NA |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot etc. |
Sample | breast cancer tissues, cell line (T5) |
Expression Pattern | up-regulated |
Function Description | We report a significant higher SRA-intron-1 relative expression in breast tumors with higher progesterone receptor contents. Using an antisense oligoribonucleotide, we have successfully reprogrammed endogenous SRA splicing and increased SRA RNA-intron-1 relative level in T5 breast cancer cells. Our results suggest that the balance coding/non-coding SRA transcripts not only characterizes particular tumor phenotypes but might also, through regulating the expression of specific genes, be involved in breast tumorigenesis and tumor progression. |
Pubmed ID | 19483093 |
Year | 2009 |
Title | Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides. |
External Links |
Links for SRA1 | GenBank HGNC lncrnadb Noncode |
Links for breast cancer | Omim Cosmic |
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