Detail
| LncRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 Sequence |
| Ensembl | ENSG00000223573 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell lines (A549, H322, H460, GLC-82, SPC-A1), lung cancer tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | INCR overexpression suppressed proliferation and invasion in lung cancer cells.TINCR was confirmed as a molecular sponge of miR-544a. We further validated that miR-544a facilitated proliferation and invasion, and miR-544a could reverse TINCR-mediated anti-proliferation and anti-invasion effect in lung cancer cells. TINCR acted as a competing endogenous RNA (ceRNA) to sequester miR-544a from its target gene FBXW7. FBXW7 suppressed proliferation and invasion,and FBXW7 knockdown abolished the inhibition of TINCR on proliferation and invasion in lung cancer cells. |
| Pubmed ID | 29324317 |
| Year | 2018 |
| Title | TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer. |
| External Links |
| Links for TINCR | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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