Detail
| LncRNA Name | TINCR |
| Synonyms | TINCR, LINC00036, NCRNA00036, PLAC2, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 Sequence |
| Ensembl | ENSG00000223573 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | GC tissues, cell lines (KATO III, NCI-N87, HGC-27, and SNU-1) |
| Expression Pattern | up-regulated |
| Function Description | miR-375 level decreased and TINCR level increased in tumor tissues.TINCR was a target of miR-375 and inhibited its expression in GC cells.Furthermore,the low expression of TINCR increased cell apoptosis and inhibited the proliferation of GC cells,while the downregulation of miR-375 reversed the function.In particular,TINCR could negatively regulate the miR-375 expression and increased the PDK1 expression in GC cells.Finally,tumor growth suppression was retarded with miR-375 downregulated in TINCR knockdown of GC cell xenografts. |
| Pubmed ID | 28744139 |
| Year | 2017 |
| Title | The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer. |
| External Links |
| Links for TINCR | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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