Detail
| LncRNA Name | TNFAIP3 |
| Synonyms | A20, AISBL, OTUD7C, TNFA1P2, A20, OTUD7C |
| Region | GRCh38_6:137867188-137883312 Sequence |
| Ensembl | ENSG00000118503 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.10 |
| Methods | qPCR, Luciferase reporter assay, RIP etc. |
| Sample | cell lines(HCT116, HT29 and LoVo) |
| Expression Pattern | differential expression |
| Function Description | LIFR-AS1 knockdown attenuated, whereas miR-29a inhibition enhanced the cellular effect of PDT on HCT116 cell proliferation and apoptosis. Furthermore, among the dysregulated mRNAs, TNFAIP3 was confirmed to be a direct target of miR-29a and exerted a similar effect to LIFR-AS1 on the cellular effects of PDT. In summary, LIFR-AS1 serves as a competitive endogenous RNA (ceRNA) for miR-29a to inhibit its expression and up-regulate downstream target TNFAIP3 expression, finally modulating the resistance of CRC to PDT. |
| Pubmed ID | 29807108 |
| Year | 2018 |
| Title | Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy. |
| External Links |
| Links for TNFAIP3 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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