Detail
| LncRNA Name | TNRC6C-AS1 |
| Synonyms | NA |
| Region | GRCh38_17:78107398-78111799 Sequence |
| Ensembl | ENSG00000204282 |
| RefSeq | NR_040071 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, luciferase reporter assay, etc. |
| Sample | human TC cell lines (ARO, Hth74), differentiated TC cell line (FTC-133), normal human thyroid cell line (HTori3). Human specimens (36 pairs of TC tissues and matched adjacent tissues). |
| Expression Pattern | down-regulated |
| Function Description | LncRNA TNRC6C-AS1 and UNC5B were overexpressed while miR-129-5p was downregulated in TC. TNRC6C-AS1 could competitively bind to miR-129-5p as a ceRNA and upregulate the expression of UNC5B, a target gene of miR- 129-5p. Therefore, the downregulation of TNRC6C-AS1 could silence UNC5B, thus suppress TC development. |
| Pubmed ID | 29893424 |
| Year | 2018 |
| Title | LncRNA TNRC6C-AS1 regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p. |
| External Links |
| Links for TNRC6C-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for thyroid cancer | Omim Cosmic |
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