Detail
| LncRNA Name | AC012065.7 |
| Synonyms | NA |
| Region | GRCh38_2:20529467-20529976 Sequence |
| Ensembl | ENSG00000279307 |
| RefSeq | NA |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | M9823/3 |
| Methods | qPCR, etc. |
| Sample | CLL peripheral blood mononuclear cells, CLL cell lines (HG3, MEC2), Burkitt lymphoma B cell line (RAMOS) |
| Expression Pattern | differential expression |
| Function Description | Finally, two novel lncRNAs (hypermethylated CRNDE and hypomethylated AC012065.7) were validated in an independent CLL sample cohort (48 samples) compared with 6 normal sorted B cell samples using quantitative pyrosequencing analysis.The methylation levels showed an inverse correlation to gene expression levels analyzed by real-time quantitative PCR. Notably, survival analysis revealed that hypermethylation of CRNDE and hypomethylation of AC012065.8 correlated with an inferior outcome |
| Pubmed ID | 27777635 |
| Year | 2016 |
| Title | Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL |
| External Links |
| Links for AC012065.7 | GenBank HGNC lncrnadb Noncode |
| Links for chronic lymphocytic leukemia | Omim Cosmic |
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