Detail
| LncRNA Name | BCAR4 |
| Synonyms | NA |
| Region | GRCh38_16:11819829-11828845 Sequence |
| Ensembl | ENSG00000262117 |
| RefSeq | NR_024049 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | cell line (ZR-75-1) |
| Expression Pattern | up-regulated |
| Function Description | We showed that ectopic expression of this gene, designated as breast cancer antiestrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells and that the intact open reading frame was required for its function. We conclude that retroviral transfer of cDNA libraries into human breast cancer cells is an efficient method for identifying genes involved in tamoxifen resistance. |
| Pubmed ID | 16778085 |
| Year | 2006 |
| Title | Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. |
| External Links |
| Links for BCAR4 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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