Detail
| LncRNA Name | TP73-AS1 |
| Synonyms | TP73-AS1, KIAA0495, PDAM |
| Region | GRCh38_1:3735601-3747336 Sequence |
| Ensembl | ENSG00000227372 |
| RefSeq | NR_033708 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | BC tissues, Breast cancer cell lines (MCF-7 and MDA-MB-231) |
| Expression Pattern | down-regulated |
| Function Description | Taken together, we demonstrated a TP73-AS1/miR-200a/ZEB1 regulating loop in breast cancer cells, which promote cancer cell invasion and migration through regulating E-cadherin and Twist expression. Suppressing TP73-AS1 expression to rescue miR-200a expression, thus to inhibit ZEB1 and Twist expression and up-regulate E-cadherin might improve breast cancer cell invasion and migration. |
| Pubmed ID | 28857253 |
| Year | 2017 |
| Title | A TP73-AS1/miR-200a/ZEB1 regulating loop promotes breast cancer cell invasion and migration. |
| External Links |
| Links for TP73-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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