Detail
| LncRNA Name | TPM1-AS |
| Synonyms | TPM1-AS1 |
| Region | GRCh38_15:63046034-63049387 Sequence |
| Ensembl | ENSG00000259498 |
| RefSeq | NR_147233 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | RIP, qPCR, Western blot |
| Sample | cell lines (KYSE140, KYSE150, KYSE180, KYSE450 ,KYSE510, SHEEC) |
| Expression Pattern | up-regulated |
| Function Description | TPM1-AS overexpression or RBM4 knockdown decreased endogenous exon 2a expression of TPM1, resulting in specifically down-regulation of TPM1variant V2 and V7 in human esophageal cancer cells. overexpression of TPM1-AS inhibited migration and filopodium formation, whereas TPM1variant V2 and V7 promoted these behaviors of human esophageal cancer cells. |
| Pubmed ID | 28754317 |
| Year | 2017 |
| Title | Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4. |
| External Links |
| Links for TPM1-AS | GenBank HGNC lncrnadb Noncode |
| Links for esophageal cancer | Omim Cosmic |
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