Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name BCAR4
   Synonyms NA
   Region GRCh38_16:11819829-11828845    Sequence
   Ensembl ENSG00000262117
   RefSeq NR_024049
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name breast cancer
   ICD-0-3 C50  
   Methods qPCR, RNAi, Western blot, Cell proliferation assay etc.
   Sample breast cancer tissues, cell lines (MDA-MB-453, MDA-MB-231, MCF-7 and T47D)
   Expression Pattern up-regulated
   Function Description

Ten different lncRNAs were applied in this study, which was reported to be associated with Notch-1. The level of these ten lncRNAs in breast tumors and adjacent normal tissues were evaluated, which suggested that HOTAIR and MALAT1 increased most significantly, and LUNAR1 and GAS5 decreased most significantly.

   Pubmed ID 26550436
   Year 2015
   Title Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5.
   External Links
   Links for  BCAR4 GenBank       HGNC       lncrnadb       Noncode
   Links for  breast cancer Omim       Cosmic

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